Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal-Reference-Cited by-同舟云学术

Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zheng Yue¹,Schubert Heidi L.²,Singh Parmit K.³⁴,Martins Laura J.¹,Engelman Alan N.³⁴,D’Orso Iván⁵,Hill Christopher P.²,Planelles Vicente¹

Affiliation:

1. Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah, USA

2. Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, Utah, USA

3. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

4. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

5. Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Abstract

CPSF6 is a cellular factor that regulates cleavage and polyadenylation of mRNAs and participates in HIV-1 infection by facilitating targeting of preintegration complexes to the chromatin. Our observations reveal a second role of CPSF6 in the HIV-1 life cycle that involves regulation of viral transcription through controlling the stability of protein phosphatase 2A, which in turn regulates the phosphorylation/dephosphorylation status of critical residues in CDK9 and Pol II.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Welch Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01098-21

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