Development of an Interferon-Gamma Release Assay (IGRA) to Aid Diagnosis of Histoplasmosis

Author:

Datta Kausik1ORCID,LaRue Richard2,Permpalung Nitipong1ORCID,Das Sukanya3,Zhang Sean1ORCID,Mehta Steinke Seema14,Bushkin Yuri3,Nosanchuk Joshua D.5,Marr Kieren A.1ORCID

Affiliation:

1. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Public Health Research Institute Center, NJMS-Rutgers, Newark, New Jersey, USA

4. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

5. Albert Einstein College of Medicine, Bronx, New York, USA

Abstract

Establishing diagnosis of latent and active histoplasmosis is challenging. Interferon gamma-release assays (IGRAs) may provide evidence of latent and active infection.

Funder

JHU Fisher Center

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference52 articles.

1. Relationship of Histoplasma capsulatum to Avian Habitats: A Review

2. Neglected endemic mycoses

3. Histoplasma variation and adaptive strategies for parasitism: new perspectives on histoplasmosis

4. Chronic Pulmonary Histoplasmosis—A Scoping Literature Review

5. Rippon JW. 1988. Histoplasmosis, p 381–423. In Rippon JW (ed), Medical mycology: pathogenic fungi and pathogenic actinomycetes, 3rd ed. WB Saunders, Philadelphia, PA.

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