Occurrence of gastric ulcers in gnotobiotic piglets colonized by Helicobacter pylori

Author:

Krakowka S1,Eaton K A1,Rings D M1

Affiliation:

1. Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, USA.

Abstract

Archival gastric tissues from 10 of 39 gnotobiotic piglets colonized with Helicobacter pylori 26695 contained stromal leukocytic inflammation along with ulcers and erosions. In contrast, gastric tissues from 54 archival control piglets were devoid of both inflammation and ulcers. These data confirm the hypothesis that H. pylori infection alone is ulcerogenic.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference47 articles.

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2. Gastritis associated with infection by Helicobacter pylori: comparative pathology in humans and swine;Bertram T.;Rev. Infect. Dis. 13:(S)714-722.,1991

3. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation;Blaser M.;Gastroenterology,1992

4. .Blaser M. 1993. Personal communication.

5. Helicobacter pylori: aggressor or innocent bystander;Clearfield H. R.;Med. Clin. North Am.,1991

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