Calcium Flux between the Endoplasmic Reticulum and Mitochondrion Contributes to Poliovirus-Induced Apoptosis-Reference-Cited by-同舟云学术

Calcium Flux between the Endoplasmic Reticulum and Mitochondrion Contributes to Poliovirus-Induced Apoptosis

Published:2010-12 Issue:23 Volume:84 Page:12226-12235
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Brisac Cynthia¹²³,Téoulé François¹²,Autret Arnaud¹²,Pelletier Isabelle¹²,Colbère-Garapin Florence¹²,Brenner Catherine³⁴,Lemaire Christophe³⁴,Blondel Bruno¹²

Affiliation:

1. Institut Pasteur, Unité de Biologie des Virus Entériques, 25 rue du Dr Roux, 75015 Paris, France

2. INSERM U994, Paris, France

3. Université Versailles Saint-Quentin, Versailles, France

4. INSERM U769, Signalisation et Physiopathologie Cardiaque, Châtenay Malabry, France

Abstract

ABSTRACT We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca 2+ ) concentration in neuroblastoma IMR5 cells, at least partly through Ca 2+ release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP 3 R) and ryanodine receptor (RyR) channels. This leads to Ca 2+ accumulation in mitochondria through the mitochondrial Ca 2+ uniporter and the voltage-dependent anion channel (VDAC). This increase in mitochondrial Ca 2+ concentration in PV-infected cells leads to mitochondrial dysfunction and apoptosis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00994-10

Reference35 articles.

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