Genome Plasticity of agr -Defective Staphylococcus aureus during Clinical Infection

Author:

Altman Deena R.12ORCID,Sullivan Mitchell J.2,Chacko Kieran I.2,Balasubramanian Divya3,Pak Theodore R.2ORCID,Sause William E.3,Kumar Krishan4,Sebra Robert25,Deikus Gintaras25,Attie Oliver2,Rose Hannah4,Lewis Martha2,Fulmer Yi4,Bashir Ali2,Kasarskis Andrew25,Schadt Eric E.25,Richardson Anthony R.6,Torres Victor J.3,Shopsin Bo34,van Bakel Harm25ORCID

Affiliation:

1. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

2. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

3. Department of Microbiology, New York University School of Medicine, New York, New York, USA

4. Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA

5. Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

6. Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Abstract

Therapy for bacteremia caused by Staphylococcus aureus is often ineffective, even when treatment conditions are optimal according to experimental protocols. Adapted subclones, such as those bearing mutations that attenuate agr -mediated virulence activation, are associated with persistent infection and patient mortality.

Funder

HHS | National Institutes of Health

New York State Department of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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