Vibrio cholerae Porin OmpU Activates Dendritic Cells via TLR2 and the NLRP3 Inflammasome-Reference-Cited by-同舟云学术

Vibrio cholerae Porin OmpU Activates Dendritic Cells via TLR2 and the NLRP3 Inflammasome

Published:2023-02-16 Issue:2 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Dhar Vinica¹,Gandhi Shraddha¹,Sakharwade Sanica C.¹,Chawla Amanpreet²,Mukhopadhaya Arunika¹^ORCID

Affiliation:

1. Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Mohali, Punjab, India

2. National Institute of Immunology (NII), Jawaharlal Nehru University, New Delhi, Delhi, India

Abstract

OmpU is one of the major porins of Vibrio cholerae , a Gram-negative human pathogen. Previously, we showed that OmpU stimulates host monocytes and macrophages and induces the production of proinflammatory mediators via activation of the Toll-like receptor 1/2 (TLR1/2)-MyD88-dependent pathways. In the present study, we show that OmpU activates murine dendritic cells (DCs) via activation of the TLR2-mediated pathway and the NLRP3 inflammasome, leading to the production of proinflammatory cytokines and DC maturation.

Funder

Indian Institute of Science Education and Research Mohali

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00332-22

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