Pre-existing T Cell Memory against Zika Virus

Author:

Schouest Blake1,Grifoni Alba1ORCID,Pham John1,Mateus Jose1,Sydney John1,Brien James D.2,De Silva Aruna D.13,Balmaseda Angel45,Harris Eva6,Sette Alessandro17,Weiskopf Daniela1ORCID

Affiliation:

1. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA

2. Saint Louis University, St. Louis, Missouri, USA

3. Department of Paraclinical Sciences, General Sir John Kotelawala Defense University, Ratmalana, Sri Lanka

4. National Virology Laboratory, National Center for Diagnosis and Reference, Ministry of Health, Managua, Nicaragua

5. Sustainable Sciences Institute, Managua, Nicaragua

6. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, USA

7. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA

Abstract

Multiple flaviviruses, including Zika virus (ZIKV) and the four serotypes of dengue virus (DENV), are prevalent in the same large tropical and equatorial areas, which are inhabited by hundreds of millions of people. The interplay of DENV and ZIKV infection is especially relevant, as these two viruses are endemic in largely overlapping regions, have significant sequence similarity, and share the same arthropod vector.

Funder

HHS | National Institutes of Health

UC | University of California, San Diego

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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