Limit of Detection for Rapid Antigen Testing of the SARS-CoV-2 Omicron and Delta Variants of Concern Using Live-Virus Culture

Author:

Stanley Sydney1,Hamel Donald J.1,Wolf Ian D.1,Riedel Stefan23ORCID,Dutta Sanjucta2,Contreras Elisa2,Callahan Cody J.2,Cheng Annie2,Arnaout Ramy234ORCID,Kirby James E.23ORCID,Kanki Phyllis J.1

Affiliation:

1. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

2. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

3. Harvard Medical School, Boston, Massachusetts, USA

4. Division of Clinical Informatics, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference24 articles.

1. US Food and Drug Administration. 2022. In vitro diagnostics EUAs—antigen diagnostic tests for SARS-CoV-2. US Food and Drug Administration, Silver Spring, MD. https://www.fda.gov/medical-devices/coronavirus-disease-2019-covid-19-emergency-use-authorizations-medical-devices/in-vitro-diagnostics-euas-antigen-diagnostic-tests-sars-cov-2. Accessed 24 January 2022.

2. Centers for Disease Control and Prevention. 2022. Overview of testing for SARS-CoV-2, the virus that causes COVID-19. Centers for Disease Control and Prevention, Atlanta, GA. https://www.cdc.gov/coronavirus/2019-ncov/hcp/testing-overview.html. Accessed 24 January 2022.

3. Diagnostic accuracy of a SARS-CoV-2 rapid antigen test in real-life clinical settings

4. A Real-World Comparison of SARS-CoV-2 Rapid Antigen Testing versus PCR Testing in Florida

5. Performance of an Antigen-Based Test for Asymptomatic and Symptomatic SARS-CoV-2 Testing at Two University Campuses — Wisconsin, September–October 2020

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