Affiliation:
1. Department of Medical Microbiology and Immunology, University of Ulm, Federal Republic of Germany.
Abstract
The capacity of the cytokines gamma interferon (IFN-gamma), interleukin-4 (IL-4), and tumor necrosis factor (TNF) to activate tuberculostatic functions in murine bone marrow-derived macrophages (BMM phi) was investigated. In confirmation of earlier findings, IFN-gamma rendered BMM phi capable of inhibiting subsequent infection with Mycobacterium bovis. In contrast, IL-4 and TNF failed to inhibit mycobacterial growth. However, in already infected BMM phi, tuberculostasis was induced by subsequent stimulation with IL-4. Although TNF alone was ineffective, it showed synergy with IFN-gamma in the stimulation of tuberculostasis. Our data suggest that not only IFN-gamma but also IL-4 and TNF participate in the control of mycobacterial growth.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference11 articles.
1. Regulation of activated macrophage antimicrobial activities. Identification of Iymphokines that cooperate with IFN--y for induction of resistance to infection;Belosevic M.;J. Immunol.,1988
2. The activation of mononuclear phagocytes: fact, fancy, and future;Cohn Z. A.;J. Immunol.,1978
3. B-cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens;Crawford R. M.;J. Immunol.,1987
4. Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages;Crowle A. J.;Infect. Immun.,1987
5. Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria;Douvas G. S.;Infect. Immun.,1985
Cited by
213 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献