Rapid Antibiotic Combination Testing for Carbapenem-Resistant Gram-Negative Bacteria within Six Hours Using ATP Bioluminescence-Reference-Cited by-同舟云学术

Rapid Antibiotic Combination Testing for Carbapenem-Resistant Gram-Negative Bacteria within Six Hours Using ATP Bioluminescence

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cai Yiying¹²,Seah Celene L.²,Leck Hui¹,Lim Tze-Peng¹,Teo Jocelyn Q.¹³^ORCID,Lee Winnie¹,Tan Thuan-Tong⁴,Koh Tse-Hsien⁵,Ee Pui Lai Rachel²,Kwa Andrea L.¹²⁶

Affiliation:

1. Department of Pharmacy, Singapore General Hospital, Singapore

2. Department of Pharmacy, National University of Singapore, Singapore

3. Saw Swee Hock School of Public Health, National University Health Systems, Singapore

4. Department of Infectious Diseases, Singapore General Hospital, Singapore

5. Department of Microbiology, Singapore General Hospital, Singapore

6. Emerging Infectious Diseases, Duke-NUS Medical School, Singapore

Abstract

To guide the timely selection of antibiotic combinations against carbapenem-resistant Gram-negative bacteria (CR-GNB), an in vitro test with a short turnaround time is essential. We developed an in vitro ATP bioluminescence assay to determine effective antibiotic combinations against CR-GNB within 6 h.

Funder

MOH | National Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00183-18

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