Efficacy of Ciprofloxacin in an Experimental Model of Escherichia coli Chorioamnionitis in Rabbits-Reference-Cited by-同舟云学术

Efficacy of Ciprofloxacin in an Experimental Model of Escherichia coli Chorioamnionitis in Rabbits

Published:2009-04 Issue:4 Volume:53 Page:1624-1627
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Launay Elise¹,Joram Nicolas¹,Jacqueline Cédric²,Miegeville Anne Francoise²,Caillon Jocelyne²³,Potel Gilles²,Roze Jean Christophe¹,Gras-Le Guen Christèle¹²

Affiliation:

1. Département de Périnatologie, Hôpital Mère Enfant CHU Nantes, Nantes 44 093, France

2. Université de Nantes, Nantes Atlantique Universités, Thérapeutiques Cliniques et Expérimentales des Infections, EA3826, UFR Médecine, 1 Rue G. Veil, Nantes F-44035, France

3. Laboratoire de Microbiologie CHU Nantes, Nantes 44 093, France

Abstract

ABSTRACT Pregnant rabbits were treated with ciprofloxacin alone or with gentamicin in a model of Escherichia coli chorioamnionitis, and the results were compared with those for untreated rabbits. The survival rate increased and the bacteremia decreased significantly in treated fetuses in comparison to controls ( P = 0.003). Nevertheless, rapid selection of resistant mutants is a major limit to ciprofloxacin applications.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00186-08

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