Relevance of Reactivity in Commercially Available Hepatitis C Virus Antibody Assays

Author:

Polywka Susanne1,Schröter Matthias1,Feucht Heinz-Hubert1,Zöllner Bernhard1,Laufs Rainer1

Affiliation:

1. Institute for Medical Microbiology and Immunology, University Hospital Eppendorf, 20246 Hamburg, Germany

Abstract

ABSTRACT Sera from 2,148 patients were tested with a third-generation microparticle enzyme immunoassay (MEIA), a confirmatory assay, and a reverse transcription-PCR. Overall, 85.6% of reactivities were confirmed, 13.2% were shown to be unspecifically reactive, and 1.2% were indeterminate. The rate of confirmed MEIA reactivities clearly depended on the strength of the reactivity.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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