Use of Rapid and Conventional Testing Technologies for Human Immunodeficiency Virus Type 1 Serologic Screening in a Rural Kenyan Reference Laboratory

Author:

Foglia Ginamarie1,Royster G. Donald2,Wasunna K. Monique3,Kibaya Rukia3,Malia Jennifer A.4,Calero Eva K.4,Sateren Warren4,Renzullo Philip O.4,Robb Merlin L.4,Birx Deborah L.4,Michael Nelson L.4

Affiliation:

1. U.S. Army Medical Research Unit—Kenya

2. Uniformed Services University School of Medicine, Bethesda, Maryland 20814

3. Kenya Medical Research Institute, Nairobi, Kenya

4. U.S. Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland 20850

Abstract

ABSTRACT We report a prospective comparison of human immunodeficiency virus type 1 testing by enzyme immunoassay and Western blot with four rapid tests of 486 subjects performed in rural Kenya. Rapid test sensitivity was 100%. Specificity ranged from 99.1 to 100%. Combined use of two Food and Drug Administration-approved rapid tests yielded a single false-positive result.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference23 articles.

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4. Brattegaard, K., J. Kouadio, M. L. Adom, R. Doorly, J. R. George, and K. M. De Cock. 1993. Rapid and simple screening and supplemental testing for HIV-1 and HIV-2 infections in west Africa. AIDS7:883-885.

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