Abstract
Two strains of coxsackie B-3 virus, indistinguishable by neutralization with acute mouse antiserum to coxsackie B-3 group virus, differ markedly in pathogenicity. One strain induces extensive mononuclear cell infiltration and necrosis in the heart, and 92% of the infected animals die by day 10 after infection. Inflammation, cardiac damage, and mortality are reduced in mice infected with the nonmyocarditic virus. Peak virus replication occurs on day 3 with both viruses. Virus concentrations decrease to undetectable levels after day 12 of infection. Cytolytic T cells could be isolated from the spleens of animals inoculated with either virus. The spleen cells preferentially lysed target cells infected with the immunizing virus strain. These results suggest that the myocarditic and nonmyocarditic viruses induce only minimally noncross-reacting virus-specific antigens on the target cell surface.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference22 articles.
1. Establishment of contracting heart muscle cell cultures;Bollon A. P.;TCA Man.,1977
2. Factors influencing host-virus interactions. tt. Alterations of Coxsackie virus infection in adult mice by cold;Boring W. D.;Proc. Soc. Exp. Biol. Med.,1956
3. Crowell R. L. 1976. Comparative genetic characteristics of picornavirus-receptor interactions p. 179-202. In R. F. Beers Jr. and E. G. Bassett (ed.) Cell membrane receptors for viruses antigens and antibodies polypeptide hormones and small molecules. Raven Press N.Y.
4. The mammalian cell-virus relationship. IV. Sustained infection of HeLa cells by Coxsackie B-3 virus and effect on superinfection;Crowell R. L.;J. Exp. Med.,1961
5. Susceptibility of gravid mice to Coxsackie virus infection;Dalldrof G.;J. Exp. Med.,1954
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