RNA Sequencing Reveals Distinct Immune Responses in the Chorioamniotic Membranes of Women with Preterm Labor and Microbial or Sterile Intra-amniotic Inflammation-Reference-Cited by-同舟云学术

RNA Sequencing Reveals Distinct Immune Responses in the Chorioamniotic Membranes of Women with Preterm Labor and Microbial or Sterile Intra-amniotic Inflammation

Published:2021-04-16 Issue:5 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Motomura Kenichiro¹²,Romero Roberto¹³⁴⁵⁶,Galaz Jose¹²,Tarca Adi L.¹²⁷,Done Bogdan¹²,Xu Yi¹²,Leng Yaozhu¹²,Garcia-Flores Valeria¹²,Arenas-Hernandez Marcia¹²,Theis Kevin R.¹⁸,Gershater Meyer¹²,Jung Eunjung¹²,Hsu Chaur-Dong¹²⁹,Gomez-Lopez Nardhy¹²⁸^ORCID

Affiliation:

1. Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS); Bethesda, Maryland, and Detroit, Michigan, USA

2. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA

3. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA

4. Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA

5. Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA

6. Detroit Medical Center, Detroit, Michigan, USA

7. Department of Computer Science, Wayne State University College of Engineering, Detroit, Michigan, USA

8. Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, Michigan, USA

9. Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Abstract

Preterm labor precedes premature birth, the leading cause of neonatal morbidity and mortality worldwide. Preterm labor can either occur in the context of microbe-associated intra-amniotic inflammation (i.e., intra-amniotic infection) or intra-amniotic inflammation in the absence of detectable microorganisms (i.e., sterile intra-amniotic inflammation).

Funder

Perinatal Research Initiative Wayne State University

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00819-20

Reference160 articles.

1. Preterm birth–associated neurodevelopmental impairment estimates at regional and global levels for 2010

2. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis