Affiliation:
1. Department of Biochemistry and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts
Abstract
ABSTRACT
The ability of many retroviruses to cause disease can be correlated to their cytopathic effect (CPE) in tissue culture characterized by an acute period of cell death and viral DNA accumulation. Here, we show that mutants of a subgroup B avian retrovirus (
Alpharetrovirus
) cause a very dramatic CPE in certain susceptible avian cells that is coincident with elevated levels of apoptosis, as measured by nuclear morphology, and persistent viral DNA accumulation. These mutants also have a broadly extended host range that includes rodent, cat, dog, monkey, and human cells (31). Previously, we have shown that the mutants exhibit diminished resistance to superinfection. The results presented here have important implications for the process of evolution of retroviruses to use distinct cellular receptors.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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