Serratia marcescens RamA Expression Is under PhoP-Dependent Control and Modulates Lipid A-Related Gene Transcription and Antibiotic Resistance Phenotypes

Author:

Mariscotti Javier F.1ORCID,García Véscovi Eleonora1ORCID

Affiliation:

1. Instituto de Biología Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Científicas y Tecnológicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina

Abstract

We demonstrate that in S. marcescens , the transcriptional regulator RamA is autoregulated and also controlled by the PhoP/PhoQ signal transduction system. We have shown that PhoP is able to directly and specifically bind to ramA , mgtE1 , mgtE2 , lpxO1 , and lpxO2 promoter regions.

Funder

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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