Experimental Evolution of the TolC-Receptor Phage U136B Functionally Identifies a Tail Fiber Protein Involved in Adsorption through Strong Parallel Adaptation

Author:

Burmeister Alita R.123ORCID,Tzintzun-Tapia Eddy12,Roush Carli12ORCID,Mangal Ivan12,Barahman Roxanna12,Bjornson Robert D.4,Turner Paul E.1256

Affiliation:

1. Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA

2. BEACON Center for the Study of Evolution in Action, East Lansing, Michigan, USA

3. Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA

4. Yale Center for Research Computing, New Haven, Connecticut, USA

5. Microbiology Program, Yale School of Medicine, New Haven, Connecticut, USA

6. Center for Phage Biology and Therapy, Yale University, New Haven, Connecticut, USA

Abstract

Antibiotic resistance is a persistent problem in health care and a factor that may help maintain bacterial diversity in natural environments. Bacteriophages (“phages”) are viruses that specifically infect bacteria.

Funder

Yale Undergraduate STARS II Fellowship

Yale Undergraduate Summer Experience Award

Felix Biotechnology

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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