Effect of Aerosol Age on the Infectivity of Airborne Pasteurella tularensis for Macaca mulatta and Man

Author:

Sawyer William D.1,Jemski Joseph V.1,Hogge Arthur L.1,Eigelsbach Henry T.1,Wolfe Elwood K.1,Dangerfield Harry G.1,Gochenour William S.1,Crozier Dan1

Affiliation:

1. U.S. Army Medical Unit and the U.S. Army Biological Laboratories, Fort Detrick, Frederick, Maryland

Abstract

Sawyer, William D. (U.S. Army Medical Unit, Fort Detrick, Frederick, Md.), Joseph V. Jemski, Arthur L. Hogge, Jr., Henry T. Eigelsbach, Elwood K. Wolfe, Harry G. Dangerfield, William S. Gochenour, Jr., and Dan Crozier . Effect of aerosol age on the infectivity of airborne Pasteurella tularensis for Macaca mulatta and man. J. Bacteriol. 91: 2180–2184. 1966.—In aging aerosols of Pasteurella tularensis SCHU-S4, the respiratory infectivity for man and Macaca mulatta decreased more rapidly than the viability of the organisms. Infectivity was diminished after 120 min, and was reduced 10-fold after 180 min. These findings confirmed previous observations made in mice and guinea pigs, and also revealed that smaller losses of infectivity were detectable in the primate hosts.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference19 articles.

1. Brain lesions in monkeys infected with Pasteurella tularensis;ARBITER D.;J. Infect. Diseases,1963

2. ARMY REGULATION 70-25. 1962. Use of volunteers as subjects of research. Department of the Army Washington D.C.

3. Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig;EIGELSBACH H. T.;J. Immunol.,1961

4. Live and killed tularemia vaccines: evaluation in animals and man. Proc. Army;EIGELSBACH H. T.;Sci. Conf. U. S. Military Acad. West Point,1962

5. Aerogenic immunization of the monkey and guinea pig with live tularemia vaccine;EIGELSBACH H. T.;Proc. Soc. Exptl. Biol. Med.,1961

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