Refining Timely Diagnosis of Early Syphilis by Using Treponema pallidum PCR or IgM Immunoblotting Next to Conventional Serology for Syphilis-Reference-Cited by-同舟云学术

Refining Timely Diagnosis of Early Syphilis by Using Treponema pallidum PCR or IgM Immunoblotting Next to Conventional Serology for Syphilis

Published:2023-06-20 Issue:6 Volume:61 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Flipse Jacky¹^ORCID,Niekamp Anne-Marie²³,Dirks Anne¹,Dukers-Muijrers Nicole H. T. M.²⁴,Hoebe Christian J. P. A.¹²³,Wolffs Petra¹^ORCID,van Loo Inge H. M.¹

Affiliation:

1. Department of Medical Microbiology, Infectious Diseases, and Infection Prevention, Maastricht University Medical Centre, Care and Public Health Research Institute, Maastricht, the Netherlands

2. Department of Sexual Health, Infectious Diseases, and Environmental Health, Living Lab Public Health, Public Health Service South Limburg, Heerlen, the Netherlands

3. Department of Social Medicine, Maastricht University, Care and Public Health Research Institute, Maastricht, the Netherlands

4. Department of Health Promotion, Maastricht University, Care and Public Health Research Institute, Maastricht, the Netherlands

Abstract

Treponema pallidum subsp. pallidum is a fastidious spirochete and the etiologic agent of syphilis, a sexually transmitted infection (STI). Syphilis diagnoses and disease staging are based on clinical findings and serologic testing.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.00112-23

Reference24 articles.

1. van Wees DAVM, van Aar FO, de Coul ELM, Staritsky LE, Sarink D, Willemstein IJM, de Vries A, Kusters JMA, den Boogert E, Alexiou ZW, Götz HM, Jansen T, van Sighem AI, Heijne JCM. 2022. Sexually transmitted infections in the Netherlands in 2021. Rijksinstituut voor Volksgezondheid en Milieu, Bilthoven, The Netherlands.

2. Retrospective Review of Treponema pallidum PCR and Serology Results: Are Both Tests Necessary?

3. Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples

4. Clinical Value of Treponema pallidum Real-Time PCR for Diagnosis of Syphilis

5. A longitudinal evaluation of Treponema pallidumPCR testing in early syphilis

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