How To Become a Top Model: Impact of Animal Experimentation on Human Salmonella Disease Research

Abstract

ABSTRACTSalmonellaserotypes are a major cause of human morbidity and mortality worldwide. Over the past decades, a series of animal models have been developed to advance vaccine development, provide insights into immunity to infection, and study the pathogenesis of humanSalmonelladisease. The successive introduction of new animal models, each suited to interrogate previously neglected aspects ofSalmonelladisease, has ushered in important conceptual advances that continue to have a strong and sustained influence on the ideas driving research onSalmonellaserotypes. This article reviews important milestones in the use of animal models to study humanSalmonelladisease and identify research needs to guide future work.