Distinct Subcellular Localization of a Type I CRISPR Complex and the Cas3 Nuclease in Bacteria-Reference-Cited by-同舟云学术

Distinct Subcellular Localization of a Type I CRISPR Complex and the Cas3 Nuclease in Bacteria

Published:2022-05-17 Issue:5 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Govindarajan Sutharsan¹,Borges Adair¹,Karambelkar Shweta¹,Bondy-Denomy Joseph¹²³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA

2. Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, California, USA

3. Innovative Genomics Institute, Berkeley, California, USA

Abstract

CRISPR-Cas systems, the prokaryotic adaptive immune systems, are largely understood using structural biology, biochemistry, and genetics. How CRISPR-Cas effectors are organized within cells is currently not well understood.

Funder

NIH Director's Early Independence award

Sandler Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00105-22

Reference57 articles.

1. CRISPR-Cas immunity in prokaryotes

2. Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

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4. Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System

5. Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex

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