Antiviral Properties of the LSD1 Inhibitor SP-2509-Reference-Cited by-同舟云学术

Antiviral Properties of the LSD1 Inhibitor SP-2509

Published:2020-09-15 Issue:19 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Harancher Mitchell R.¹,Packard Jessica E.²,Cowan Shane P.²,DeLuca Neal A.¹^ORCID,Dembowski Jill A.¹²^ORCID

Affiliation:

1. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania, USA

Abstract

Treatment of HSV-1-infected cells with SP-2509 blocked viral DNA replication, gene expression after the onset of DNA replication, and virus production. These data support a potential new role for LSD1 in the regulation of viral DNA replication and successive steps in the virus life cycle, and further highlight the promising potential to utilize LSD1 inhibition as an antiviral approach.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00974-20

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