Identification of One Critical Amino Acid Residue of the Nucleoprotein as a Determinant for In Vitro Replication Fitness of Influenza D Virus-Reference-Cited by-同舟云学术

Identification of One Critical Amino Acid Residue of the Nucleoprotein as a Determinant for In Vitro Replication Fitness of Influenza D Virus

Published:2021-08-25 Issue:18 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yu Jieshi¹^ORCID,Huang Chen¹,Sheng Zizhang²,Wang Zhao³,Li Feng¹,Wang Dan¹

Affiliation:

1. Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, USA

2. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York, USA

3. Department of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA

Abstract

Little is known about the virus infection and production mechanism for newly discovered influenza D virus (IDV), which utilizes bovines as a primary reservoir, with frequent spillover to new hosts, including swine. In this study, we showed that of two well-characterized IDVs, 660/13 replicated more efficiently (approximately 100-fold higher) than OK/11.

Funder

Agricultural Experiment Station of the University of Kentucky

William Robert Mills Chair Endowment Fund

SDSU Agricultural Experiment Station Hatch grants

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00971-21

Reference85 articles.