Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection-Reference-Cited by-同舟云学术

Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jones Sean T.¹²,Guo Kejun¹³,Cooper Emily H.⁴,Dillon Stephanie M.¹,Wood Cheyret⁴,Nguyen David H.¹,Shen Guannan⁴,Barrett Bradley S.¹,Frank Daniel N.¹,Kroehl Miranda⁴,Janoff Edward N.¹²⁵,Kechris Katerina⁴,Wilson Cara C.¹²³,Santiago Mario L.¹²³^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

2. Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

3. RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

4. Center for Innovative Design and Analysis, Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

5. Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado, USA

Abstract

The gut is a major site of early HIV-1 replication and pathogenesis. Extensive CD4 + T cell depletion in this compartment results in a compromised epithelial barrier that facilitates the translocation of microbes into the underlying lamina propria and systemic circulation, resulting in chronic immune activation.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00976-22

Reference64 articles.

1. B cells in HIV infection and disease

2. Serlin MH, Dieterich D. 2007. Gastrointestinal disorders in HIV, p 251–260. In Volberding PA, Sande MA, Greene WC, Lange JMA (ed), Global HIV/AIDS Medicine. W.B. Saunders Company, New York, NY.

3. CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

4. Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection

5. Th17 cells, HIV and the gut mucosal barrier

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. HIV-1 infection is associated with depletion of germinal center B cells and a decrease in IgA⁺plasma cells in the GI tract;2024-05-20

2. Endogenous retroelement expression in the gut microenvironment of people living with HIV-1;eBioMedicine;2024-05

3. A Two-Faced Gut Microbiome: Butyrogenic and Proinflammatory Bacteria Predominate in the Intestinal Milieu of People Living with HIV from Western Mexico;International Journal of Molecular Sciences;2024-04-29

4. Endogenous Retroelement Expression in the Gut Microenvironment of People Living with HIV-1;2023-11-07

5. HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria;Nature Communications;2023-10-10