Immune Escape Adaptive Mutations in Hemagglutinin Are Responsible for the Antigenic Drift of Eurasian Avian-Like H1N1 Swine Influenza Viruses-Reference-Cited by-同舟云学术

Immune Escape Adaptive Mutations in Hemagglutinin Are Responsible for the Antigenic Drift of Eurasian Avian-Like H1N1 Swine Influenza Viruses

Published:2022-08-24 Issue:16 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Xu Chengzhi¹,Zhang Naixin¹,Yang Yuying¹,Liang Wenhua¹,Zhang Yaping¹,Wang Jingfei¹,Suzuki Yasuo²,Wu Yunpu¹,Chen Yan¹,Yang Huanliang¹,Qiao Chuanling¹,Chen Hualan¹^ORCID

Affiliation:

1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

2. Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan

Abstract

The antigenic changes that occur continually in the evolution of influenza A viruses remain a great challenge for the effective control of disease outbreaks. Here, we identified three amino acid substitutions (at positions 190, 230, and 269) in the HA of EA H1N1 SIVs that determine viral antigenicity and result in escape from neutralizing monoclonal antibodies.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00971-22

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