Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) Can Coinfect the Same Hepatocyte in the Liver of Patients with Chronic HCV and Occult HBV Infection-Reference-Cited by-同舟云学术

Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) Can Coinfect the Same Hepatocyte in the Liver of Patients with Chronic HCV and Occult HBV Infection

Published:2005-12-15 Issue:24 Volume:79 Page:15578-15581
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rodríguez-Íñigo E.¹,Bartolomé J.¹,Ortiz-Movilla N.¹,Platero C.²,López-Alcorocho J. M.¹,Pardo M.¹,Castillo I.¹,Carreño V.¹

Affiliation:

1. Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain

2. Departamento de Electrónica, Automática e Informática Industrial, Universidad Politécnica de Madrid, Madrid, Spain

Abstract

ABSTRACT In this work, we have shown that hepatitis C virus (HCV) and hepatitis B virus (HBV) can coexist in the same hepatocyte using double fluorescent in situ hybridization in liver biopsy samples from patients with chronic HCV infection with occult HBV infection. Digital image analysis of hybridization signals showed that the HBV DNA levels in coinfected hepatocytes were lower than those in cells infected only with HBV. This finding supports the hypothesis of inhibition of HBV replication by HCV. Furthermore, HCV RNA levels were lower in coinfected cells than in cells infected only with HCV, suggesting that HBV may also inhibit HCV replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.24.15578-15581.2005

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