Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus

Published:2012-04-15 Issue:8 Volume:78 Page:2768-2774
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Brown Ashley N.¹,Smith Kathryn¹,Samuels Tova A.²,Lu Jiangrui²,Obare Sherine O.²,Scott Maria E.¹

Affiliation:

1. Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan, USA

2. Department of Chemistry, Western Michigan University, Kalamazoo, Michigan, USA

Abstract

ABSTRACT We show here that silver nanoparticles (AgNP) were intrinsically antibacterial, whereas gold nanoparticles (AuNP) were antimicrobial only when ampicillin was bound to their surfaces. Both AuNP and AgNP functionalized with ampicillin were effective broad-spectrum bactericides against Gram-negative and Gram-positive bacteria. Most importantly, when AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.06513-11

Reference44 articles.

1. Hybrids of silver nanoparticles with amphiphilic hyperbranched macromolecules exhibiting antimicrobial properties;Aymonier C;Chem. Commun. (Camb.),2002

2. Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos;Bar-Ilan O;Small,2009

3. Nanoparticles as vehicles for delivery of photodynamic therapy agents;Bechet D;Trends Biotechnol.,2008

4. Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies, and toxicity;Boisselier E;Chem. Soc. Rev.,2009

5. On the enhanced antibacterial activity of antibiotics mixed with gold nanoparticles;Burygin GL;Nanoscale Res. Lett.,2009

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