Affiliation:
1. Department of Microbiology, University of Nottingham, City Hospital, Nottingham NG5 1PH, England
Abstract
A new cephalosporin is described that overcomes, in a novel way, the general susceptibility of this group of agents to enterobacterial β-lactamases. The new compound carries a substituent that is released on cleavage of the β-lactam ring and then exhibits antibacterial activity in its own right. The possible therapeutic benefits of such an antibiotic are discussed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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