Nationwide Investigation of Extended-Spectrum β-Lactamases, Metallo-β-Lactamases, and Extended-Spectrum Oxacillinases Produced by Ceftazidime-Resistant Pseudomonas aeruginosa Strains in France

Author:

Hocquet Didier1,Plésiat Patrick1,Dehecq Barbara1,Mariotte Pierre1,Talon Daniel1,Bertrand Xavier1

Affiliation:

1. Centre National de Référence de la Résistance aux Antibiotiques, Laboratoire associé P. aeruginosa, Hôpital Jean Minjoz, Besançon, France

Abstract

ABSTRACT A nationwide study aimed to identify the extended-spectrum β-lactamases (ESBLs), metallo-β-lactamases (MBLs), and extended-spectrum oxacillinases (ES-OXAs) in a French collection of 140 clinical Pseudomonas aeruginosa isolates highly resistant to ceftazidime. Six ESBLs (PER-1, n = 3; SHV-2a, n = 2; VEB-1a, n = 1), four MBLs (VIM-2, n = 3; IMP-18, n = 1), and five ES-OXAs (OXA-19, n = 4; OXA-28, n = 1) were identified in 13 isolates (9.3% of the collection). The prevalence of these enzymes is still low in French clinical P. aeruginosa isolates but deserves to be closely monitored.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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