Detection of Histoplasma capsulatum Antigenuria by Ultrafiltration of Samples with False-Negative Results-Reference-Cited by-同舟云学术

Detection of Histoplasma capsulatum Antigenuria by Ultrafiltration of Samples with False-Negative Results

Published:2008-04 Issue:4 Volume:15 Page:726-728
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Egan Lindsey¹²³,Connolly Patricia A.¹²³,Fuller Deanna¹²³,Davis Thomas E.¹²³,Witt John¹²³,Knox Kenneth S.¹²³,Hage Chadi A.¹²³,Wheat L. Joseph¹²³

Affiliation:

1. MiraVista Diagnostics, Indianapolis, Indiana

2. Indiana University School of Medicine, Department of Pathology, Wishard Memorial Hospital, 1001 West Tenth Street, Indianapolis, Indiana 46202

3. Indiana University School of Medicine, Department of Pulmonary Medicine, Roudebush Veterans’ Administration Hospital, 1481 West Tenth Street, Indianapolis, Indiana 46202

Abstract

ABSTRACT Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00493-07

Reference3 articles.

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