How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection-Reference-Cited by-同舟云学术

How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection

Published:2019-12 Issue:24 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Buffalo Cosmo Z.¹,Iwamoto Yuichiro¹,Hurley James H.¹²,Ren Xuefeng¹^ORCID

Affiliation:

1. Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA

2. Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA

Abstract

The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of cell surface proteins to disrupt host immunity and promote the viral replication cycle. Nef counteracts host defenses by sequestering and/or degrading its targets via the endocytic and secretory pathways. Nef does this by physically engaging a number of host trafficking proteins.

Funder

Andrew Dougherty Vision Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01322-19

Reference187 articles.

1. HIV-1 Accessory Proteins Adapt Cellular Adaptors to Facilitate Immune Evasion

2. HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment