Identification of the First Gene Transfer Agent (GTA) Small Terminase in Rhodobacter capsulatus and Its Role in GTA Production and Packaging of DNA

Author:

Sherlock D.1,Leong J. X.1,Fogg P. C. M.1ORCID

Affiliation:

1. Biology Department, University of York, York, United Kingdom

Abstract

Random transfer of any and all genes between bacteria could be influential in the spread of virulence or antimicrobial resistance genes. Discovery of the true prevalence of GTAs in sequenced genomes is hampered by their apparent similarity to bacteriophages. Our data allowed the prediction of small terminases in diverse GTA producer species, and defining the characteristics of a “GTA-type” terminase could be an important step toward novel GTA identification. Importantly, the GTA small terminase shares many features with its phage counterpart. We propose that the GTA terminase complex could become a streamlined model system to answer fundamental questions about double-stranded DNA (dsDNA) packaging by viruses that have not been forthcoming to date.

Funder

Royal Society

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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