The alg-1 Gene Is Necessary for Orsay Virus Replication in Caenorhabditis elegans

Author:

Cubillas Ciro12,Sandoval Del Prado Luis Enrique12,Goldacker Sydney12,Fujii Chika12,Pinski Amanda N.12,Zielke Jon12,Wang David12ORCID

Affiliation:

1. Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA

2. Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA

Abstract

All viruses are obligate intracellular parasites that recruit the cellular machinery of the host they infect to support their own proliferation. We used Caenorhabditis elegans and its only known infecting virus, Orsay virus, to identify host proteins relevant for virus infection.

Funder

HHS | National Institutes of Health

American Heart Association

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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