Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essential for Viral Infectivity-Reference-Cited by-同舟云学术

Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essential for Viral Infectivity

Published:2022-05-11 Issue:9 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lucas Cormac J.¹²,Davenport Bennett J.¹,Carpentier Kathryn S.¹,Tinega Alex N.¹,Morrison Thomas E.¹^ORCID

Affiliation:

1. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA

2. RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado, USA

Abstract

Alphaviruses are human pathogens that cause both debilitating acute and chronic musculoskeletal disease and potentially fatal encephalitis. In this study, we determined that two highly conserved phenylalanine residues in the alphavirus E1 glycoprotein are required for fusion of viral and host cell membranes and viral entry into target cells.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00064-22

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