Affiliation:
1. Divisions of Chemistry and Biochemistry and of Biology and Experimental Medicine, Institutum Divi Thomae, Cincinnati, Ohio 45206
Abstract
By a short-term combined prophylactic-therapeutic procedure, the following compounds were found to be active against staphylococcal infections in Swiss mice: γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid (GABOB), δ-amino-valeric acid (DAVA), ε-aminocaproic acid (EACA),
trans
-4-aminomethylcyclohexanecarboxylic acid (
trans
-AMCHA), taurine, and cysteic acid. Many of these compounds had displayed limited or no activity by a previously used prophylactic procedure. Although DAVA and GABOB were the most potent of the straight-chain ω-amino acids,
trans
-AMCHA displayed the greatest antistaphylococcic activity of the ω-amino acids thus far investigated. Homocarnosine (γ-aminobutyrl histidine, which also was active by the prophylactic procedure) equalled
trans
-AMCHA in activity. Taurine was similar in potency to DAVA, and the activity of cysteic acid approximated that of EACA.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference12 articles.
1. Some properties of the antifibrinolytically active isomers of aminomethylcyclohexanecarboxylic acid;Dubber A. J. C.;Lancet,1964
2. Three antistaphylococcic factors from ox brain;Kroenberg B.;Nature (London),1963
3. The metabolism of anserine and carnosine in normal and vitamin E-deficient rabbits;McManus I. R.;J. Biol. Chem.,1960
4. Studies on antifibrinolytic activities of co-amino acids and related compounds;Mangyo M.;J. Jap. Biochem. Soc.,1963
5. Quantitative determination of epsilon-aminocaproic acid in blood;Mori A.;Jap. J. Brain Physiol.,1963