Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants-Reference-Cited by-同舟云学术

Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants

Published:2004-06 Issue:6 Volume:72 Page:3638-3642
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Motameni Amir-Reza T.¹,Juncadella Ignacio J.¹,Ananthanarayanan Shobana K.¹,Hedrick Michael N.¹,Huet-Hudson Yvette¹,Anguita Juan¹

Affiliation:

1. Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223

Abstract

ABSTRACT A Salmonella enterica serovar Typhimurium aroA -deficient delivery system was used to target the immunosuppressive protein Salp15 to antigen-presenting cells. In vitro and in vivo infections with Salp15-containing Salmonella resulted in an impaired CD4 + -T-cell activation, suggesting that the protein was produced by antigen-presenting cells in a physiologically active form.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.6.3638-3642.2004

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