Suboptimal Dosing of Fluconazole in Critically Ill Patients: Time To Rethink Dosing

Author:

Muilwijk Eline W.12,de Lange Dylan W.3,Schouten Jeroen A.4,Wasmann Roeland E.12ORCID,ter Heine Rob1,Burger David M.1,Colbers Angela1,Haas Pieter J.5,Verweij Paul E.26,Pickkers Peter27,Brüggemann Roger J.12ORCID

Affiliation:

1. Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands

2. Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands

3. Department of Intensive Care and National Poison Information Center, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands

4. Department of Intensive Care, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

5. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

6. Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Medical Microbiology, Nijmegen, The Netherlands

7. Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands

Abstract

Fluconazole is frequently used for the treatment of invasive Candida infections in critically ill patients. However, alterations in renal functions might influence fluconazole clearance. Therefore, our objective was to study the impact of renal function on the population pharmacokinetics of fluconazole in critically ill patients with various degrees of renal function or undergoing continuous renal replacement therapy (CRRT). This was an open-label, multicenter observational study.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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