Genotypic Study of Pneumocystis jirovecii in Human Immunodeficiency Virus-Positive Patients in Thailand-Reference-Cited by-同舟云学术

Genotypic Study of Pneumocystis jirovecii in Human Immunodeficiency Virus-Positive Patients in Thailand

Published:2005-05 Issue:5 Volume:43 Page:2104-2110
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Siripattanapipong Suradej¹,Worapong Jeerapun²,Mungthin Mathirut³,Leelayoova Saovanee³,Tan-ariya Peerapan¹

Affiliation:

1. Department of Microbiology, Faculty of Science, Mahidol UniversityRama VI Rd.

2. Center for Biotechnology and Department of Biotechnology, Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakornpratom 73170, Thailand

3. Department of Parasitology, Phramongkutklao College of Medicine, Ratchawithi Rd., Bangkok 10400

Abstract

ABSTRACT Pneumocystis jirovecii is one of the common opportunistic infections in human immunodeficiency virus (HIV)-infected patients in Thailand. Information regarding genotypic and epidemiological of this organism in Thai patients is not available. We analyzed the genotypes of 28 P. jirovecii -positive specimens from bronchoalveolar lavage and sputum samples from HIV-infected Thai patients based on nucleotide variations of the internal transcribed spacer regions 1 and 2 of the rRNA gene. Thirteen genotypes were the same as previously reported outside Thailand. Ten genotypes, which included Bp, Er, Eq, Ic, Ir, Ip, Rc, Rp, Qb, and Qq, were new. Ir and Rp were unique and dominant types observed in HIV-infected Thai patients. Thirteen specimens (46.4%) were infected with a single type of P. jirovecii , and fifteen (53.6%) were mixed infections. These differences may be used as genotypic markers for studying the epidemiology and transmission of P. jirovecii in the Thai population.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.43.5.2104-2110.2005

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