In Vitro Activity of Voriconazole against Prototheca wickerhamii : Comparative Evaluation of Sensititre and NCCLS M27-A2 Methods of Detection-Reference-Cited by-同舟云学术

In Vitro Activity of Voriconazole against Prototheca wickerhamii : Comparative Evaluation of Sensititre and NCCLS M27-A2 Methods of Detection

Published:2005-05 Issue:5 Volume:43 Page:2520-2522
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Linares Maria José¹,Solís Francisco¹,Casal Manuel¹

Affiliation:

1. Department of Microbiology, Faculty of Medicine, University of Córdoba, 14004 Córdoba, Spain

Abstract

ABSTRACT A total of 104 Prototheca wickerhamii isolates and two control strains were tested for susceptibility to voriconazole using the Sensititre YeastOne colorimetric antifungal plate and NCCLS reference method. Voriconazole was highly active against all isolates, with an MIC at which 90% of isolates were inhibited of ≤0.5 μg/ml. Comparison of MICs obtained with the Sensititre product and the NCCLS method demonstrated agreement (100% ± 2 log 2 dilutions) between the two methods. Voriconazole may offer an option for the treatment of Prototheca sp. infections, and its efficacy should be established through clinical experience.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.43.5.2520-2522.2005

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