Effect of Melanin Biosynthesis Inhibition on the Antifungal Susceptibility of Chromoblastomycosis Agents-Reference-Cited by-同舟云学术

Effect of Melanin Biosynthesis Inhibition on the Antifungal Susceptibility of Chromoblastomycosis Agents

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Heidrich Daiane¹,Pagani Danielle Machado²^ORCID,Koehler Alessandra¹,Alves Karine de Oliveira³,Scroferneker Maria Lúcia¹³

Affiliation:

1. Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

2. Postgraduate Program of Agricultural and Environmental Microbiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

3. Department of Microbiology, Immunology and Parasitology, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

Abstract

Chromoblastomycosis (CBM) is a chronic subcutaneous infection caused by genera of melanized fungi: Fonsecaea , Cladophialophora , Phialophora , Exophiala , and Rhinocladiella . Melanin is a virulence factor known to influence antifungal susceptibility. A specific inhibitor of melanin biosynthesis is tricyclazole.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00546-21

Reference32 articles.

1. Chromoblastomycosis

2. Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species

3. Challenges in the Therapy of Chromoblastomycosis

4. Treating chromoblastomycosis with systemic antifungals

5. Melanin and chromoblastomycosis agents: Characterization, functions, and relation with antifungals

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