Affiliation:
1. Connaught Medical Research Laboratories, University of Toronto, Willowdale, Ontario, Canada
Abstract
Serum neutralization antibody and immunoglobulin responses in 30 individuals were studied in paired serum samples which had been obtained before and 2 to 3 weeks after the administration of a recall dose of rabies tissue culture vaccine. The immune reaction consisted of a predominantly immunoglobulin G (IgG) antibody response. Also, a significant increase in neutralizing antibody titers was observed, but without a consistently correlated change of the IgG levels in the individual serum samples. The radial immunodiffusion test appears to contain the elements necessary for the development of a routine test to determine rabies antibody in single serum samples.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference16 articles.
1. Stability of human immunoglobulin levels;Allansmith M.;Proc. Soc. Exp. Biol. Med.,1967
2. Atanasiu P. 1966. Quantitative assay and potency test of antirabies serum p. 167-172. In Laboratory techniques in rabies. W.H.O. Monogr. Ser. no. 23 2nd ed.
3. Sequences of synthesis of -y-l macroglobulin and -y-2 globulin antibodies during primary and secondary responses to proteins, salmonella antigens, and phage;Bauer D. C.;J. Exp. Med.,1963
4. Regulation of antibody synthesis against Escherichia coli endotoxin. I. Suppressive effect of endogenously produced and passively transferred antibodies;Britton S.;J. Immunol.,1968
5. Antibodies and immunoglobulins. II. Normal development and changes in disease;Fahey J. L.;J. Amer. Med. Ass.,1965
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献