Affiliation:
1. Department of Allergy and Clinical Immunology and Clinical Laboratories, National Jewish Hospital and Research Center, Denver, Colorado 80206
Abstract
Sera from normal rabbits were shown to have antibodies that bound radiolabeled test antigens derived from many taxonomically unrelated bacteria. Sera from rabbits that had been immunized with sonically treated material of 12 different bacteria, including
M. bovis
strain BCG, had antibodies that bound not only radiolabeled homologous test antigens but also radiolabeled antigens from many unrelated bacteria. Binding by normal and immunized sera to radiolabeled test antigens was inhibited by homologous unlabeled test antigens but not by substances such as bovine serum albumin, polyvinylpyrrolidone, sheep erythrocytes, and endotoxin. The broad range of shared or cross-reactivity among antigens in bacteria may explain the presence of antibodies to many bacteria in sera from normal humans and previously unimmunized experimental animals. The presence of these antibodies raises the question whether resistance to many bacterial infections may be partly due to immune mechanisms, whether cellular or humoral, that have been stimulated by unrelated bacteria.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
62 articles.
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