Resistance Levels and rpoB Gene Mutations among In Vitro-Selected Rifampin-Resistant Mycobacterium tuberculosis Mutants-Reference-Cited by-同舟云学术

Resistance Levels and rpoB Gene Mutations among In Vitro-Selected Rifampin-Resistant Mycobacterium tuberculosis Mutants

Published:2006-08 Issue:8 Volume:50 Page:2860-2862
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Huitric Emma¹²,Werngren Jim¹²,Juréen Pontus¹²,Hoffner Sven¹

Affiliation:

1. Department of Bacteriology, Swedish Institute for Infectious Disease Control Solna, and

2. Department of Microbiology, Tumor and Cell Biology Center, Karolinska Institute, Stockholm, Sweden

Abstract

ABSTRACT The distribution and resistance levels of 189 in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants of Beijing and other genotypes were determined. Apart from a higher amount of codon 522 point mutations and large deletions, a spread of mutations similar to that reported for clinical isolates was seen. Most mutations were correlated with high-level resistance; a lower level, or a MIC of <16 mg/liter, was associated with codon 522 mutations. Multiple mutations were detected in two Beijing mutants.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00303-06

Reference27 articles.

1. Ahmad, S., and E. Mokaddas. 2005. The occurrence of rare rpoB mutations in rifampicin-resistant clinical Mycobacterium tuberculosis isolates from Kuwait. Int. J. Antimicrob. Agents26:205-212.

2. Persistence of antibiotic resistant bacteria

3. Physiological Cost of Rifampin Resistance Induced In Vitro in Mycobacterium tuberculosis

4. Bobadilla-del-Valle, M., A. Ponce-de-Leon, C. Arenas-Huertero, G. Vargas-Alarcon, M. Kato-Maeda, P. M. Small, P. Couary, G. M. Ruiz-Palacios, and J. Sifuentes-Osornio. 2001. rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis identified by polymerase chain reaction single-stranded conformational polymorphism. Emerg. Infect. Dis.7:1010-1013.

5. Cole, S. T., and A. Telenti. 1995. Drug resistance in Mycobacterium tuberculosis. Eur. Respir. J.20(Suppl.):701s-713s.

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