Affiliation:
1. Department of Bacteriology, University of Sydney, Sydney, N.S.W. 2006, Australia
Abstract
Serum from normal mammals agglutinated and immobilized nonpathogenic
Leptospira biflexa
and agglutinated avirulent lines of pathogenic serotypes
L. icterohaemorrhagiae
and
L. zanoni
. Virulent lines of
L. icterohaemorrhagiae
and
L. zanoni
were not affected, nor were any of three strains of
L. pomona
, one of which was avirulent. The active principle in serum was a β-macroglobulin which was heat-labile and reduced by 2-mercaptoethanol, and acted in conjunction with complement and lysozyme; it was absorbable from serum by Formalin-treated susceptible leptospires. The Formalin-stable receptor antigen, named “Z antigen,” is associated with virulence rather than pathogenicity, but may not be a determinant of virulence.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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