Comparison of Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum-Reference-Cited by-同舟云学术

Comparison of Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum

Published:2016-08 Issue:8 Volume:23 Page:732-734
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Chow Siu-Kei¹,Atienza Ederlyn E.¹,Cook Linda¹,Prince Harry²,Slev Patricia³,Lapé-Nixon Mary²,Jerome Keith R.¹⁴

Affiliation:

1. Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA

2. Focus Diagnostics Reference Laboratory, San Juan Capistrano, California, USA

3. Department of Pathology, University of Utah, Salt Lake City, Utah, USA

4. The Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Abstract

ABSTRACT Serology remains critical for diagnosing hepatitis D virus (HDV) infection, which affects 15 to 20 million people worldwide, but the literature on characterizing commercial enzyme immunoassays (EIAs) dates back to 15 years ago. We evaluated 2 commercial EIAs currently available for detecting anti-HDV antibodies. The DiaSorin assay demonstrated 100% sensitivity and specificity. Using a modified cutoff value, the Cusabio assay demonstrated a sensitivity of 81.3% and specificity of 90.9%. Our data show that recently developed EIAs are reliable for anti-HDV antibody detection.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00028-16

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