Herpesvirus Saimiri-Transformed Human CD4 + T-Cell Lines: an Efficient Target Cell System for the Analysis of Human Immunodeficiency Virus-Specific Cytotoxic CD8 + T-Lymphocyte Activity-Reference-Cited by-同舟云学术

Herpesvirus Saimiri-Transformed Human CD4 + T-Cell Lines: an Efficient Target Cell System for the Analysis of Human Immunodeficiency Virus-Specific Cytotoxic CD8 + T-Lymphocyte Activity

Published:1998-02 Issue:2 Volume:72 Page:1627-1631
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bauer Monika¹,Lucchiari-Hartz Maria²,Fickenscher Helmut³,Eichmann Klaus²,McKeating Jane⁴,Meyerhans Andreas¹

Affiliation:

1. Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, 79104 Freiburg,1

2. Max-Planck-Institut für Immunbiologie, 79108 Freiburg,2 and

3. Institut für Klinische und Molekulare Virologie, Universität Erlangen Nürnberg, 91054 Erlangen,3 Germany, and

4. School of Animal and Microbial Sciences, University of Reading, Reading, United Kingdom4

Abstract

ABSTRACT Herpesvirus saimiri growth-transformed human CD4 + T lymphocytes were examined for their suitability as a target cell system for investigating human immunodeficiency virus (HIV)-specific HLA class I-restricted cytotoxic T-cell activity. Besides CD4, they express the chemokine receptors CCR5 and CXCR4, the common coreceptors of HIV. They are infectible by a range of HIV strains, including primary isolates, becoming efficient targets for CD8-positive HIV-specific cytotoxic T lymphocytes.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.2.1627-1631.1998

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3. Growth transformation of human T cells;Immunology of Infection;2002

4. Herpesvirus saimiri;Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences;2001-04-29

5. Use of Herpesvirus saimiri-immortalized macaque CD4+ T cell clones as stimulators and targets for assessment of CTL responses in macaque/AIDS models;Journal of Immunological Methods;1999-11