Ponatinib Represses Latent HIV-1 by Inhibiting AKT-mTOR-Reference-Cited by-同舟云学术

Ponatinib Represses Latent HIV-1 by Inhibiting AKT-mTOR

Published:2023-06-15 Issue:6 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Huang Ting¹²,Cai Jinfeng¹³^ORCID,Wang Peipei⁴,Zhou Jiasheng¹³,Zhang Haitao⁵,Wu Ziqi¹³,Zhao Jiacong¹³,Huang Zhanlian⁴,Deng Kai¹³⁶^ORCID

Affiliation:

1. Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

2. School of Medicine, Sun Yat-sen University, Shenzhen, China

3. Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

4. Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

5. Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China

6. Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

Abstract

Although antiretroviral therapy (ART) is effective in suppressing viral replication, it does not cure HIV-1 infection due to the presence of the viral latent reservoir. Rather than reactivating the latent viruses, the “block and lock” strategy aims to shift the viral reservoir to a deeper state of transcriptional silencing, thus preventing viral rebound after ART interruption.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00067-23

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