Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis-Reference-Cited by-同舟云学术

Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis

Published:2009-02 Issue:2 Volume:53 Page:839-842
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rodrigues Raquel F.¹,Charret Karen S.¹,da Silva Edson F.²,Echevarria Áurea²,Amaral Verônica F.³,Leon Leonor L.¹,Canto-Cavalheiro Marilene M.¹

Affiliation:

1. Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil CEP 21045-900

2. Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, RJ, Brazil

3. Departamento de Imunobiologia, Instituto de Biologia, Universidade Federal Fluminense—Niterói, RJ, Brazil

Abstract

ABSTRACT The efficacy of two mesoionic derivatives (MI-H-H and MI-4-OCH 3 ) was evaluated in CBA/J mice infected with Leishmania amazonensis . Treatment with these compounds demonstrated that the MI-4-OCH 3 derivative and the reference drug meglumine antimoniate (Glucantime) presented significant activity relative to an untreated control. No apparent hepatic or renal toxicity due to these mesoionic compounds was found.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00062-08

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