A Human Milk Factor Susceptible to Cathepsin D Inhibitors Enhances Human Immunodeficiency Virus Type 1 Infectivity and Allows Virus Entry into a Mammary Epithelial Cell Line-Reference-Cited by-同舟云学术

A Human Milk Factor Susceptible to Cathepsin D Inhibitors Enhances Human Immunodeficiency Virus Type 1 Infectivity and Allows Virus Entry into a Mammary Epithelial Cell Line

Published:2000-01-15 Issue:2 Volume:74 Page:1004-1007
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

El Messaoudi Kamal¹,Thiry Lise F.¹,Liesnard Corinne²,Van Tieghem Nicole³,Bollen Alex¹,Moguilevsky Nicole¹

Affiliation:

1. Department of Applied Genetics, Faculty of Science,1

2. Department of Virology,2 and

3. Department of Microbiology,3 Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium

Abstract

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) growth in lymphocyte cultures was increased when the virus inoculum was incubated in breast milk. The enhancing effect of milk was abolished by anti-cathepsin D antibody or by pepstatin A, a cathepsin D inhibitor. The cathepsin D-producing CD4-negative MCF7 mammary cells supported the growth of some HIV-1 isolates. An MCF7 line chronically producing HIV-1 IIIb was obtained. Cathepsin D may induce conformational modification of viral gp120, allowing direct interaction with a coreceptor. We demonstrated the presence of CXCR4 mRNA in MCF7 cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.2.1004-1007.2000

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